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Calciphylaxis: risk factors, diagnosis, and treatment.


ABSTRACT: Calciphylaxis is a rare but devastating condition that has continued to challenge the medical community since its early descriptions in the scientific literature many decades ago. It is predominantly seen in patients with chronic kidney failure treated with dialysis (uremic calciphylaxis) but is also described in patients with earlier stages of chronic kidney disease and with normal kidney function. In this review, we discuss the available medical literature regarding risk factors, diagnosis, and treatment of both uremic and nonuremic calciphylaxis. High-quality evidence for the evaluation and management of calciphylaxis is lacking at this time due to its rare incidence and poorly understood pathogenesis and the relative paucity of collaborative research efforts. We hereby provide a summary of recommendations developed by a multidisciplinary team for patients with calciphylaxis.

SUBMITTER: Nigwekar SU 

PROVIDER: S-EPMC4696752 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Calciphylaxis: risk factors, diagnosis, and treatment.

Nigwekar Sagar U SU   Kroshinsky Daniela D   Nazarian Rosalynn M RM   Goverman Jeremy J   Malhotra Rajeev R   Jackson Vicki Ann VA   Kamdar Mihir M MM   Steele David J R DJ   Thadhani Ravi I RI  

American journal of kidney diseases : the official journal of the National Kidney Foundation 20150507 1


Calciphylaxis is a rare but devastating condition that has continued to challenge the medical community since its early descriptions in the scientific literature many decades ago. It is predominantly seen in patients with chronic kidney failure treated with dialysis (uremic calciphylaxis) but is also described in patients with earlier stages of chronic kidney disease and with normal kidney function. In this review, we discuss the available medical literature regarding risk factors, diagnosis, an  ...[more]

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