Quantification of experimental venous thrombus resolution by longitudinal nanogold-enhanced micro-computed tomography.

ABSTRACT:

Introduction

The assessment of thrombus size following treatments directed at preventing thrombosis or enhancing its resolution has generally relied on physical or histological methods. This cross-sectional design imposes the need for increased numbers of animals for experiments. Micro-computed tomography (microCT) has been used to detect the presence of venous thrombus in experimental models but has yet to be used in a quantitative manner. In this study, we investigate the use of contrast-enhanced microCT for the longitudinal assessment of experimental venous thrombus resolution.

Materials and methods

Thrombi induced by stenosis of the inferior vena cava in mice were imaged by contrast-enhanced microCT at 1, 7 and 14 days post-induction (n=18). Thrombus volumes were determi

SUBMITTER: Grover SP 

PROVIDER: S-EPMC4697135 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature