Ontology highlight
ABSTRACT:
SUBMITTER: Castro MA
PROVIDER: S-EPMC4697365 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Nature genetics 20151130 1
Genetic risk for breast cancer is conferred by a combination of multiple variants of small effect. To better understand how risk loci might combine, we examined whether risk-associated genes share regulatory mechanisms. We created a breast cancer gene regulatory network comprising transcription factors and groups of putative target genes (regulons) and asked whether specific regulons are enriched for genes associated with risk loci via expression quantitative trait loci (eQTLs). We identified 36 ...[more]