A white matter stroke model in the mouse: axonal damage, progenitor responses and MRI correlates.

ABSTRACT: Subcortical white matter stroke is a common stroke subtype but has had limited pre-clinical modeling. Recapitulating this disease process in mice has been impeded by the relative inaccessibility of the subcortical white matter arterial supply to induce white matter ischemia in isolation. In this report, we detail a subcortical white matter stroke model developed in the mouse and its characterization with a comprehensive set of MRI, immunohistochemical, neuronal tract tracing and electron microscopic studies. Focal injection of the vasoconstrictor endothelin-1 into the subcortical white matter produces an infarct core that develops a maximal MRI signal by day 2, which is comparable in relative size and location to human subcortical stroke. Immunohistochemical studies indicate that oligodend

SUBMITTER: Sozmen EG 

PROVIDER: S-EPMC4697458 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature