Genome-wide association study of posttraumatic stress disorder in a cohort of Iraq-Afghanistan era veterans.

ABSTRACT:

Background

Posttraumatic stress disorder (PTSD) is a psychiatric disorder that can develop after experiencing traumatic events. A genome-wide association study (GWAS) design was used to identify genetic risk factors for PTSD within a multi-racial sample primarily composed of U.S. veterans.

Methods

Participants were recruited at multiple medical centers, and structured interviews were used to establish diagnoses. Genotypes were generated using three Illumina platforms and imputed with global reference data to create a common set of SNPs. SNPs that increased risk for PTSD were identified with logistic regression, while controlling for gender, trauma severity, and population substructure. Analyses were run separately in non-Hispanic black (NHB; n = 949) and non-Hispanic white (

SUBMITTER: Ashley-Koch AE 

PROVIDER: S-EPMC4697755 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature