Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury.

ABSTRACT: It has become increasingly clear that the functions of eosinophils extend beyond host defense and allergy to metabolism and tissue regeneration. These influences have strong potential to be relevant in worm infections in which eosinophils are prominent and parasites rely on the host for nutrients to support growth or reproduction. The aim of this study was to investigate the mechanism underlying the observation that eosinophils promote growth of Trichinella spiralis larvae in skeletal muscle. Our results indicate that IL-4 and eosinophils are necessary for normal larval growth and that eosinophils from IL-4 competent mice are sufficient to support growth. The eosinophil-mediated effect operates in the absence of adaptive immunity. Following invasion by newborn larvae, host gene expression

SUBMITTER: Huang L 

PROVIDER: S-EPMC4697774 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature