Cervical HPV natural history among young Western Cape, South African women: The randomized control EVRI Trial.

ABSTRACT:

Objective

The objective of this analysis was to assess human papillomavirus (HPV) infection persistence and incidence 7-months post-enrollment by HPV vaccine study arm (vaccine or placebo).

Methods

HIV-negative, sexually active women aged 16-24 years in the Western Cape, South Africa, were enrolled in the EVRI Trial and were randomized to receive 4-valent HPV vaccine or placebo. Cervical specimens were collected at enrollment and at the 7-month visit and were genotyped for HPV. HPV prevalence, persistence, and incidence were calculated. Prevalence ratios and odds ratios were calculated to assess factors associated with a prevalent and incident HPV infection.

Results

HPV incidence rates were marginally higher for the placebo group (n = 163) compared to the vaccine grou

SUBMITTER: Sudenga SL 

PROVIDER: S-EPMC4698060 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature