Prenatal cocaine exposure, illicit-substance use and stress and craving processes during adolescence.

ABSTRACT:

Background

Prenatal cocaine exposure (PCE) is associated with increased rates of illicit-substance use during adolescence. In addition, both PCE and illicit-substance use are associated with alterations in cortico-striato-limbic neurocircuitry, development of which is ongoing throughout adolescence. However, the relationship between illicit-substance use, PCE and functional neural responses has not previously been assessed concurrently.

Methods

Sixty-eight adolescents were recruited from an ongoing longitudinal study of childhood and adolescent development. All participants had been followed since birth. Functional magnetic resonance imaging (fMRI) data were acquired during presentation of personalized stressful, favorite-food and neutral/relaxing imagery scripts and compare

SUBMITTER: Yip SW 

PROVIDER: S-EPMC4698087 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature