Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study.

ABSTRACT:

Background

Over 20% of pregnancies in patients with systemic lupus erythematosus (SLE) and/or antiphospholipid antibodies (APL) result in an adverse pregnancy outcome (APO) related to abnormal placentation. The ability to identify, early in pregnancy, patients who are destined for poor outcomes would significantly impact care of this high-risk population. In nonautoimmune patients, circulating angiogenic factors are dysregulated in disorders of placentation, such as preeclampsia (PE) and fetal growth restriction.

Objective

We sought to determine whether early dysregulation of circulating angiogenic factors can predict APO in high-risk SLE and/or APL pregnancies.

Study design

We used data and samples from the Predictors of Pregnancy Outcome: Biomarkers in APL Syndrome

SUBMITTER: Kim MY 

PROVIDER: S-EPMC4698098 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature