Critical Roles of STAT3 in β-Adrenergic Functions in the Heart.

ABSTRACT:

Background

β-Adrenergic receptors (βARs) play paradoxical roles in the heart. On one hand, βARs augment cardiac performance to fulfill the physiological demands, but on the other hand, prolonged activations of βARs exert deleterious effects that result in heart failure. The signal transducer and activator of transcription 3 (STAT3) plays a dynamic role in integrating multiple cytokine signaling pathways in a number of tissues. Altered activation of STAT3 has been observed in failing hearts in both human patients and animal models. Our objective is to determine the potential regulatory roles of STAT3 in cardiac βAR-mediated signaling and function.

Methods and results

We observed that STAT3 can be directly activated in cardiomyocytes by β-adrenergic agonists. To follow up this

SUBMITTER: Zhang W 

PROVIDER: S-EPMC4698100 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature