Microvascular Perfusion Changes following Transarterial Hepatic Tumor Embolization.

ABSTRACT:

Purpose

To quantify changes in tumor microvascular (< 1 mm) perfusion relative to commonly used angiographic endpoints.

Materials and methods

Rabbit Vx2 liver tumors were embolized with 100-300-μm LC Bead particles to endpoints of substasis or complete stasis (controls were not embolized). Microvascular perfusion was evaluated by delivering two different fluorophore-conjugated perfusion markers (ie, lectins) through the catheter before embolization and 5 min after reaching the desired angiographic endpoint. Tumor microvasculature was labeled with an anti-CD31 antibody and analyzed with fluorescence microscopy for perfusion marker overlap/mismatch. Data were analyzed by analysis of variance and post hoc test (n = 3-5 per group; 18 total).

Results

Mean microvascular den

SUBMITTER: Johnson CG 

PROVIDER: S-EPMC4698187 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature