Lipid metabolism in patients infected with Nef-deficient HIV-1 strain.

ABSTRACT:

Background

HIV protein Nef plays a key role in impairing cholesterol metabolism in both HIV infected and bystander cells. The existence of a small cohort of patients infected with Nef-deficient strain of HIV presented a unique opportunity to test the effect of Nef on lipid metabolism in a clinical setting.

Methods

Here we report the results of a study comparing six patients infected with Nef-deficient strain of HIV (ΔNefHIV) with six treatment-naïve patients infected with wild-type HIV (WT HIV). Lipoprotein profile, size and functionality of high density lipoprotein (HDL) particles as well as lipidomic and microRNA profiles of patient plasma were analyzed.

Results

We found that patients infected with ΔNefHIV had lower proportion of subjects with plasma HDL-C levels <1

SUBMITTER: Low H 

PROVIDER: S-EPMC4698210 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature