Mapping Thalamocortical Functional Connectivity in Chronic and Early Stages of Psychotic Disorders.

ABSTRACT:

Background

There is considerable evidence that the thalamus is abnormal in psychotic disorders. Resting-state functional magnetic resonance imaging has revealed an intriguing pattern of thalamic dysconnectivity in psychosis characterized by reduced prefrontal cortex (PFC) connectivity and increased somatomotor-thalamic connectivity. However, critical knowledge gaps remain with respect to the onset, anatomical specificity, and clinical correlates of thalamic dysconnectivity in psychosis.

Methods

Resting-state functional magnetic resonance imaging was collected on 105 healthy subjects and 148 individuals with psychosis, including 53 early-stage psychosis patients. Using all 253 subjects, the thalamus was parceled into functional regions of interest (ROIs) on the basis of conne

SUBMITTER: Woodward ND 

PROVIDER: S-EPMC4698230 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature