Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue.

ABSTRACT:

Background

Despite the increasing prevalence of heart failure with preserved ejection fraction (HFpEF) in humans, there are no evidence-based therapies for HFpEF. Clinical studies suggest a relationship between obesity-associated dysfunctional adipose tissue (AT) and HFpEF. However, an apparent obesity paradox exists in some HF populations with a higher body mass index. We sought to determine whether HFpEF exerted effects on AT and investigated the involved mechanisms.

Methods and results

Mice underwent d-aldosterone infusion, uninephrectomy, and were given 1% saline for 4 weeks. HFpEF mice developed hypertension, left ventricular hypertrophy, and diastolic dysfunction and had higher myocardial natriuretic peptide expression. Although body weights were similar in HFpEF and s

SUBMITTER: Valero-Munoz M 

PROVIDER: S-EPMC4698901 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature