Clinical utility of gene-expression profiling in women with early breast cancer: an overview of systematic reviews.

ABSTRACT:

Purpose

This overview systematically evaluates the clinical utility of using Oncotype DX and MammaPrint gene-expression profiling tests to direct treatment decisions in women with breast cancer. The findings are intended to inform an updated recommendation from the Evaluation of Genomic Applications in Practice and Prevention Working Group.

Methods

Evidence reported in systematic reviews evaluating the clinical utility of Oncotype DX and MammaPrint, as well as the ability to predict treatment outcomes, change in treatment decisions, and cost-effectiveness, was qualitatively synthesized.

Results

Five systematic reviews found no direct evidence of clinical utility for either test. Indirect evidence showed Oncotype DX was able to predict treatment effects of adjuvant che

SUBMITTER: Marrone M 

PROVIDER: S-EPMC4698966 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature