Longitudinal Metabolomic Profiling of Amino Acids and Lipids across Healthy Pregnancy.

ABSTRACT: Pregnancy is characterized by a complexity of metabolic processes that may impact fetal development and ultimately, infant health outcomes. However, our understanding of whole body maternal and fetal metabolism during this critical life stage remains incomplete. The objective of this study is to utilize metabolomics to profile longitudinal patterns of fasting maternal metabolites among a cohort of non-diabetic, healthy pregnant women in order to advance our understanding of changes in protein and lipid concentrations across gestation, the biochemical pathways by which they are metabolized and to describe variation in maternal metabolites between ethnic groups. Among 160 pregnant women, amino acids, tricarboxylic acid (TCA) cycle intermediates, keto-bodies and non-esterified fatty acids wer

SUBMITTER: Lindsay KL 

PROVIDER: S-EPMC4699222 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature