Postnatal Cytomegalovirus Infection and the Risk for Bronchopulmonary Dysplasia.

ABSTRACT:

Importance

Postnatally acquired cytomegalovirus (CMV) is typically benign in term infants but in very low-birth-weight (VLBW) infants can cause pneumonitis and sepsislike illness. Whether postnatal CMV infection results in long-term pulmonary sequelae in these infants is unknown.

Objective

To investigate the association between postnatal CMV infection and bronchopulmonary dysplasia (BPD) and mortality in a large multicenter cohort of VLBW infants.

Design, setting, and participants

Conducted between October 2014 and June 2015, this propensity-matched retrospective cohort study involved 101,111 hospitalized VLBW (<1500 g) infants at 348 neonatal intensive care units in the United States from 1997 to 2012. We matched infants with postnatal CMV infection 1:1 to comparison

SUBMITTER: Kelly MS 

PROVIDER: S-EPMC4699399 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature