Association between promoter polymorphisms of OPN gene and cancer risk: a meta-analysis.

ABSTRACT:

Background

Results of the association between polymorphisms of osteopontin (OPN) gene promoter region and risk of cancer were inconclusive. The aim of this meta-analysis was to elucidate whether OPN promoter polymorphisms were associated with cancer risk.

Methods

Electronic databases including PubMed, Web of Science, and Chinese National Knowledge Infrastructure were systematically searched. Odd ratios (ORs) and their 95% confidential interval (CI) were used to assess the strength of association between OPN promoter polymorphisms and cancer risks.

Results

Nine studies were finally included in this meta-analysis. For OPN rs17524488 polymorphism, carriers of GG or -/G genotype were significantly associated with increased cancer risk compared with wild-type -/- carriers,

SUBMITTER: Liu J 

PROVIDER: S-EPMC4699542 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature