Resting State Brain Entropy Alterations in Relapsing Remitting Multiple Sclerosis.

ABSTRACT: Brain entropy (BEN) mapping provides a novel approach to characterize brain temporal dynamics, a key feature of human brain. Using resting state functional magnetic resonance imaging (rsfMRI), reliable and spatially distributed BEN patterns have been identified in normal brain, suggesting a potential use in clinical populations since temporal brain dynamics and entropy may be altered in disease conditions. The purpose of this study was to characterize BEN in multiple sclerosis (MS), a neurodegenerative disease that affects millions of people. Since currently there is no cure for MS, developing treatment or medication that can slow down its progression represents a high research priority, for which validating a brain marker sensitive to disease and the related functional impairments is esse

SUBMITTER: Zhou F 

PROVIDER: S-EPMC4699711 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature