Cell to Cell Variability of Radiation-Induced Foci: Relation between Observed Damage and Energy Deposition.

ABSTRACT: Most studies that aim to understand the interactions between different types of photon radiation and cellular DNA assume homogeneous cell irradiation, with all cells receiving the same amount of energy. The level of DNA damage is therefore generally determined by averaging it over the entire population of exposed cells. However, evaluating the molecular consequences of a stochastic phenomenon such as energy deposition of ionizing radiation by measuring only an average effect may not be sufficient for understanding some aspects of the cellular response to this radiation. The variance among the cells associated with this average effect may also be important for the behaviour of irradiated tissue. In this study, we accurately estimated the distribution of the number of radiation-induced γH2AX

SUBMITTER: Gruel G 

PROVIDER: S-EPMC4699766 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature