New Strains Intended for the Production of Inactivated Polio Vaccine at Low-Containment After Eradication.

ABSTRACT: Poliomyelitis has nearly been eradicated through the efforts of the World Health Organization's Global Eradication Initiative raising questions on containment of the virus after it has been eliminated in the wild. Most manufacture of inactivated polio vaccines currently requires the growth of large amounts of highly virulent poliovirus, and release from a production facility after eradication could be disastrous; WHO have therefore recommended the use of the attenuated Sabin strains for production as a safer option although it is recognised that they can revert to a transmissible paralytic form. We have exploited the understanding of the molecular virology of the Sabin vaccine strains to design viruses that are extremely genetically stable and hyperattenuated. The viruses are based on the

SUBMITTER: Knowlson S 

PROVIDER: S-EPMC4699825 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature