Triamterene Enhances the Blood Pressure Lowering Effect of Hydrochlorothiazide in Patients with Hypertension.

ABSTRACT:

Background

Triamterene, because of its potassium-sparing properties, is frequently used in combination with hydrochlorothiazide (HCTZ) to treat patients with hypertension. By inhibiting the epithelial sodium channel (ENaC) in the cortical collecting duct, triamterene reduces potassium secretion, thus reducing the risk of hypokalemia. Whether triamterene has an independent effect on blood pressure (BP) has not been well studied.

Objective

To determine if triamterene provides an effect to further lower BP in patients treated with HCTZ.

Design

We conducted an observational study using electronic medical record data from the Indiana Network for Patient Care. Participants were 17,291 patients with the diagnosis of hypertension between 2004 and 2012.

Main measures

BP

SUBMITTER: Tu W 

PROVIDER: S-EPMC4700022 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature