Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD.

ABSTRACT:

Background

Respiratory virus infections are commonly associated with COPD exacerbations, but little is known about the mechanisms linking virus infection to exacerbations. Pathogenic mechanisms in stable COPD include oxidative and nitrosative stress and reduced activity of histone deacetylase-2 (HDAC2), but their roles in COPD exacerbations is unknown. We investigated oxidative and nitrosative stress (O&NS) and HDAC2 in COPD exacerbations using experimental rhinovirus infection.

Methods

Nine subjects with COPD (Global Initiative for Chronic Obstructive Lung Disease stage II), 10 smokers, and 11 nonsmokers were successfully infected with rhinovirus. Markers of O&NS-associated cellular damage, and inflammatory mediators and proteases were measured in sputum, and HDAC2 activity

SUBMITTER: Footitt J 

PROVIDER: S-EPMC4700054 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature