Chronic mild stress alters the somatostatin receptors in the rat brain.

ABSTRACT:

Rationale

The involvement of somatostatin (SST) and its receptors in the pathophysiology of depression and stress has been evidenced by numerous studies.

Objectives

The purpose of the present study was to find whether chronic mild stress (CMS), an animal model of depression, affects the SST receptors in the rat brain and pituitary, as well as the level of SST in plasma.

Methods

In CMS model, rats were subjected to 2 weeks of stress and behaviorally characterized using the sucrose consumption test into differently reacting groups based on their response to stress, i.e., stress-reactive (anhedonic), stress-non-reactive (resilient), and invert-reactive rats (characterized by excessive sucrose intake). We measured specific binding of [125I]Tyr3-Octreotide, expression of m

SUBMITTER: Faron-Gorecka A 

PROVIDER: S-EPMC4700104 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature