AGE-RAGE signal generates a specific NF-κB RelA "barcode" that directs collagen I expression.

ABSTRACT: Advanced glycation end products (AGEs) are sugar-modified biomolecules that accumulate in the body with advancing age, and are implicated in the development of multiple age-associated structural and functional abnormities and diseases. It has been well documented that AGEs signal via their receptor RAGE to activate several cellular programs including NF-κB, leading to inflammation. A large number of stimuli can activate NF-κB; yet different stimuli, or the same stimulus for NF-κB in different cellular settings, produce a very different transcriptional landscape and physiological outcome. The NF-κB barcode hypothesis posits that cellular network dynamics generate signal-specific post-translational modifications, or a "barcode" to NF-κB, and that a signature "barcode" mediates a specific gen

SUBMITTER: Peng Y 

PROVIDER: S-EPMC4700418 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature