Genetic diversity and natural selection footprints of the glycine amidinotransferase gene in various human populations.

ABSTRACT: The glycine amidinotransferase gene (GATM) plays a vital role in energy metabolism in muscle tissues and is associated with multiple clinically important phenotypes. However, the genetic diversity of the GATM gene remains poorly understood within and between human populations. Here we analyzed the 1,000 Genomes Project data through population genetics approaches and observed significant genetic diversity across the GATM gene among various continental human populations. We observed considerable variations in GATM allele frequencies and haplotype composition among different populations. Substantial genetic differences were observed between East Asian and European populations (FST = 0.56). In addition, the frequency of a distinct major GATM haplotype in these groups was congruent with populat

SUBMITTER: Khan A 

PROVIDER: S-EPMC4700420 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature