Bcl6 Sets a Threshold for Antiviral Signaling by Restraining IRF7 Transcriptional Program.

ABSTRACT: The coordination of restraining and priming of antiviral signaling constitute a fundamental aspect of immunological functions. However, we currently know little about the molecular events that can translate the pathogenic cues into the appropriate code for antiviral defense. Our present study reports a specific role of B cell lymphoma (Bcl)6 as a checkpoint in the initiation of the host response to cytosolic RNA viruses. Remarkably, Bcl6 specifically binds to the interferon-regulatory factor (IRF)7 loci and restrains its transcription, thereby functioning as a negative regulator for interferon (IFN)-β production and antiviral responses. The signal-controlled turnover of the Bcl6, most likely mediated by microRNA-127, coordinates the antiviral response and inflammatory sequelae. Accordingly

SUBMITTER: Xu F 

PROVIDER: S-EPMC4700451 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature