Immune cell impact of three differently coated lipid nanocapsules: pluronic, chitosan and polyethylene glycol.

ABSTRACT: Lipid nanocapsules (NCs) represent promising tools in clinical practice for diagnosis and therapy applications. However, the NC appropriate functionalization is essential to guarantee high biocompatibility and molecule loading ability. In any medical application, the immune system-impact of differently functionalized NCs still remains to be fully understood. A comprehensive study on the action exerted on human peripheral blood mononuclear cells (PBMCs) and major immune subpopulations by three different NC coatings: pluronic, chitosan and polyethylene glycol-polylactic acid (PEG) is reported. After a deep particle characterization, the uptake was assessed by flow-cytometry and confocal microscopy, focusing then on apoptosis, necrosis and proliferation impact in T cells and monocytes. Cell f

SUBMITTER: Farace C 

PROVIDER: S-EPMC4700454 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature