Serum Autotaxin/ENPP2 correlates with insulin resistance in older humans with obesity.

ABSTRACT:

Objective

Autotaxin (ATX) is an adipocyte-derived lysophospholipase D that generates the lipid signaling molecule lysophosphatidic acid (LPA). The ATX/LPA pathway in adipose tissue has recently been implicated in obesity and insulin resistance in animal models, but the role of circulating ATX in humans remains unclear. The aim of the present study was to determine the relationship between serum ATX and insulin resistance.

Methods

Older (60-75 years), nondiabetic human participants with overweight or obesity (BMI 25-37 kg m(-2) ) were characterized for metabolic phenotype including measures of energy, glucose, and lipid homeostasis. The relationship between serum ATX and metabolic parameters was then determined using correlative and predictive statistics.

Results

Serum

SUBMITTER: Reeves VL 

PROVIDER: S-EPMC4700540 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature