Enhanced cytotoxic function of natural killer and CD3+CD56+ cells in cord blood after culture.

ABSTRACT: Rate of immune reconstitution directly correlates with the number of hematopoietic stem cells infused and is particularly delayed in patients undergoing cord blood (CB) transplantation (CBT). Methods to increase the number of CB natural killer (NK) cells have the potential to improve immune reconstitution after CBT. NK cells are the first lymphocyte population to recover after hematopoietic stem cells transplantation and are central to preventing early relapse and infection. CB NK cells are low in number and are known to be incomplete in maturation and require activation for effective function. Here, we report a clinically relevant ex vivo expansion method that increases the number of activated CB NK cells. We report a multilog increase in NK cell number when CB mononuclear cells are cocul

SUBMITTER: Tomchuck SL 

PROVIDER: S-EPMC4700822 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature