Synbiotics and gastrointestinal function-related quality of life after elective colorectal cancer resection.

ABSTRACT:

Background

Synbiotics (combination of prebiotics and probiotics) may serve as a supportive dietary supplement-based strategy after colectomy for cancer. The potential benefits of early postoperative administration of synbiotics on the gastrointestinal function-related quality of life inpatients were explored.

Methods

Patients who underwent elective colectomy were prospectively enrolled and randomized to receive either synbiotics (n=38) or placebo (n=37) on the day they tolerated liquid diet and for 15 days thereafter. Primary endpoints were Gastro-Intestinal Quality of Life Index (GIQLI) questionnaire assessments at 1, 3 and 6 months postoperatively. Secondary endpoints were functional bowel disorders ("diarrhea", "constipation") assessed by EORTC QLQ-C30.

Results

Pat

SUBMITTER: Theodoropoulos GE 

PROVIDER: S-EPMC4700848 | biostudies-literature | 2016 Jan-Mar

REPOSITORIES: biostudies-literature