Individual Members of the Microbiota Disproportionately Modulate Host Innate Immune Responses.

ABSTRACT: Predicting host health status based on microbial community structure is a major goal of microbiome research. An implicit assumption of microbiome profiling for diagnostic purposes is that the proportional representation of different taxa determine host phenotypes. To test this assumption, we colonized gnotobiotic zebrafish with zebrafish-derived bacterial isolates and measured bacterial abundance and host neutrophil responses. Surprisingly, combinations of bacteria elicited immune responses that do not reflect the numerically dominant species. These data are consistent with a quantitative model in which the host responses to commensal species are additive but where various species have different per capita immunostimulatory effects. For example, one species has a high per capita immunosupp

SUBMITTER: Rolig AS 

PROVIDER: S-EPMC4701053 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature