Expression Differentiation Is Constrained to Low-Expression Proteins over Ecological Timescales.

ABSTRACT: Protein expression level is one of the strongest predictors of protein sequence evolutionary rate, with high-expression protein sequences evolving at slower rates than low-expression protein sequences largely because of constraints on protein folding and function. Expression evolutionary rates also have been shown to be negatively correlated with expression level across human and mouse orthologs over relatively long divergence times (i.e., ∼100 million years). Long-term evolutionary patterns, however, often cannot be extrapolated to microevolutionary processes (and vice versa), and whether this relationship holds for traits evolving under directional selection within a single species over ecological timescales (i.e., <5000 years) is unknown and not necessarily expected. Expression is a met

SUBMITTER: Margres MJ 

PROVIDER: S-EPMC4701091 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature