Genetical Genomics of Behavior: A Novel Chicken Genomic Model for Anxiety Behavior.

ABSTRACT: The identification of genetic variants responsible for behavioral variation is an enduring goal in biology, with wide-scale ramifications, ranging from medical research to evolutionary theory on personality syndromes. Here, we use for the first time a large-scale genetical genomics analysis in the brains of chickens to identify genes affecting anxiety as measured by an open field test. We combine quantitative trait locus (QTL) analysis in 572 individuals and expression QTL (eQTL) analysis in 129 individuals from an advanced intercross between domestic chickens and Red Junglefowl. We identify 10 putative quantitative trait genes affecting anxiety behavior. These genes were tested for an association in the mouse Heterogeneous Stock anxiety (open field) data set and human GWAS data sets for b

SUBMITTER: Johnsson M 

PROVIDER: S-EPMC4701096 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature