Ontology highlight
ABSTRACT:
SUBMITTER: McBurney KL
PROVIDER: S-EPMC4701097 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Genetics 20151103 1
Histones are among the most conserved proteins known, but organismal differences do exist. In this study, we examined the contribution that divergent amino acids within histone H3 make to cell growth and chromatin structure in Saccharomyces cerevisiae. We show that, while amino acids that define histone H3.3 are dispensable for yeast growth, substitution of residues within the histone H3 α3 helix with human counterparts results in a severe growth defect. Mutations within this domain also result ...[more]