Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy.

ABSTRACT: Adoptive cell transfer (ACT) of purified naive, stem cell memory, and central memory T cell subsets results in superior persistence and antitumor immunity compared with ACT of populations containing more-differentiated effector memory and effector T cells. Despite a clear advantage of the less-differentiated populations, the majority of ACT trials utilize unfractionated T cell subsets. Here, we have challenged the notion that the mere presence of less-differentiated T cells in starting populations used to generate therapeutic T cells is sufficient to convey their desirable attributes. Using both mouse and human cells, we identified a T cell-T cell interaction whereby antigen-experienced subsets directly promote the phenotypic, functional, and metabolic differentiation of naive T cells. Thi

SUBMITTER: Klebanoff CA 

PROVIDER: S-EPMC4701537 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature