Time trends in intracranial bleeding associated with direct oral anticoagulants: a 5-year cohort study.

ABSTRACT:

Background

Over the past 5 years, dabigatran, rivaroxaban and apixaban were approved for stroke prevention. Phase III studies have shown a lower risk of intracranial bleeding with these direct oral anticoagulants than with warfarin; however, there is a lack of real-life data to validate this. We analyzed time trends in atraumatic intracranial bleeding from 2009 to 2013 among patients prescribed oral anticoagulants and those not prescribed oral anticoagulants.

Methods

We used ICD-10-CA (enhanced Canadian version of the 10th revision of the International Statistical Classification of Diseases and Related Health Problems) codes to identify all patients with atraumatic intracranial bleeding who presented to our neurosurgical centre (serving a population of more than 1.2 million)

SUBMITTER: Hogg K 

PROVIDER: S-EPMC4701652 | biostudies-literature | 2015 Oct-Dec

REPOSITORIES: biostudies-literature