Parameters of Calcium Metabolism Fluctuated during Initiation or Changing of Antipsychotic Drugs.

ABSTRACT:

Objective

Serum parameters of calcium homeostasis were measured based on previously published evidence linking osteoporotic fractures and/or bone/mineral loss with antipsychotics.

Methods

Prospective, four-week, time-series trial was conducted and study population consisted of patients of both genders, aged 35-85 years, admitted within the routine practice, with acute psychotic symptoms, to whom an antipsychotic drug was either introduced or substituted. Serial measurements of serum calcium, phosphorous, magnesium, 25(OH)D, parathyroid hormone, calcitonin, osteocalcin and C-telopeptide were made from patient venous blood samples.

Results

Calcium serum concentrations significantly decreased from baseline to the fourth week (2.42±0.12 vs. 2.33±0.16 mmol/L, p=0.022, n=25

SUBMITTER: Milovanovic DR 

PROVIDER: S-EPMC4701691 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature