Plasma pharmacokinetics and synovial concentrations of S-flurbiprofen plaster in humans.

ABSTRACT:

Purpose

The purpose of this study is to investigate the pharmacokinetics and deep tissue penetration capability of the newly developed S-flurbiprofen plaster (SFPP) in humans.

Methods

Study 1: SFPP tape-type patch (2-60 mg) was applied to the lower back for 24 h in healthy adult volunteers. S-flurbiprofen (SFP) plasma concentration was measured over time to examine SFP pharmacokinetics. Study 2: SFPP (20 mg) was applied for 12 h to the affected knee of osteoarthritis (OA) patients who were scheduled for total knee arthroplasty. Deep tissues (synovial tissue and synovial fluid) were collected during surgery to compare SFP concentrations after application of SFPP or a commercially available flurbiprofen (FP) gel-type patch.

Results

Study 1: The plasma concentration of S

SUBMITTER: Yataba I 

PROVIDER: S-EPMC4701782 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature