Insulin Resistance Negatively Influences the Muscle-Dependent IGF-1-Bone Mass Relationship in Premenarcheal Girls.

ABSTRACT:

Context

IGF-1 promotes bone growth directly and indirectly through its effects on skeletal muscle. Insulin and IGF-1 share a common cellular signaling process; thus, insulin resistance may influence the IGF-1-muscle-bone relationship.

Objective

We sought to determine the effect of insulin resistance on the muscle-dependent relationship between IGF-1 and bone mass in premenarcheal girls.

Design, setting, and participants

This was a cross-sectional study conducted at a university research center involving 147 girls ages 9 to 11 years.

Main outcome measures

Glucose, insulin, and IGF-1 were measured from fasting blood samples. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated from glucose and insulin. Fat-free soft tissue (FFST) mass and b

SUBMITTER: Kindler JM 

PROVIDER: S-EPMC4701844 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature