Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes.

ABSTRACT: CONTEXT:Maternal obesity and gestational diabetes mellitus (GDM) can both contribute to adverse neonatal outcomes. The extent to which this may be mediated by differences in placental metabolism and nutrient transport remains to be determined. OBJECTIVE:Our objective was to examine whether raised maternal body mass index (BMI) and/or GDM contributed to a resetting of the expression of genes within the placenta that are involved in energy sensing, oxidative stress, inflammation, and metabolic pathways. METHODS:Pregnant women from Spain were recruited as part of the "Study of Maternal Nutrition and Genetics on the Foetal Adiposity Programming" survey at the first antenatal visit (12-20 weeks of gestation) and stratified according to prepregnancy BMI and the incidence of GDM. At delivery, pla

SUBMITTER: Martino J 

PROVIDER: S-EPMC4701853 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature