Insights from the predicted epitope similarity between Mycobacterium tuberculosis virulent factors and its human homologs.

ABSTRACT: Mycobacterium tuberculosis is known to be associated with several autoimmune diseases such as systemic lupus erythematous, rheumatoid arthritis and multiple sclerosis. This is attributed to sequence similarity between virulent factors and human proteins. Therefore, it is of interest to identify such regions in the virulent factors to assess potential autoimmune related information. M. tb specific virulent factors were downloaded from the VFDB database and its human homologs were identified using the sequence comparison search tool BLASTP. Both virulent proteins and their corresponding human homologs were further scanned for epitopes (B cell and HLA class I and II allele specific) using prediction programs (BCPRED and NETMHC). Data shows the presence of matching 22 B-cell, 79 HLA class II a

SUBMITTER: Gutlapalli VR 

PROVIDER: S-EPMC4702028 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature