Study of regulatory promoter polymorphism (-248 G>A) of Bax gene in patients with gastric cancer in the northern provinces of Iran.

ABSTRACT:

Aim

The aim of this study is to evaluate the polymorphism in Bax gene and its association with some clinical pathology traits in gastric cancer.

Background

Gastric cancer is considered as the fourth most common cancer in the north and northwest of Iran. Bcl2 family has a key role in regulation of apoptosis, and any changes in the expression of Bcl2 lead to cancer.

Patients and methods

Blood samples were collected from 100 cases and 89 controls in the northern provinces of Iran to evaluate promoter polymorphism (-248GResultsThe result of this study demonstrated the existence of polymorphism in the above-mentioned region of Bax gene. Sixty-nine patients (%69) with genotype GG and 31 patients (%31) w

SUBMITTER: Mirmajidi SH 

PROVIDER: S-EPMC4702040 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature