Enhancement of Contralesional Motor Control Promotes Locomotor Recovery after Unilateral Brain Lesion.

ABSTRACT: There have been controversies on the contribution of contralesional hemispheric compensation to functional recovery of the upper extremity after a unilateral brain lesion. Some studies have demonstrated that contralesional hemispheric compensation may be an important recovery mechanism. However, in many cases where the hemispheric lesion is large, this form of compensation is relatively limited, potentially due to insufficient connections from the contralesional hemisphere to the paralyzed side. Here, we used a new procedure to increase the effect of contralesional hemispheric compensation by surgically crossing a peripheral nerve at the neck in rats, which may provide a substantial increase in connections between the contralesional hemisphere and the paralyzed limb. This surgical procedur

SUBMITTER: Hua XY 

PROVIDER: S-EPMC4702126 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature