Associations of Urinary Uromodulin with Clinical Characteristics and Markers of Tubular Function in the General Population.

ABSTRACT:

Background and objectives

Allelic variants in UMOD, the gene coding for uromodulin, are associated with rare tubulointerstitial kidney disorders and risk of CKD and hypertension in the general population. The factors associated with uromodulin excretion in the normal population remain largely unknown, and were therefore explored in this study.

Design, setting, participants, & measurements

Urinary uromodulin excretion was measured using a validated ELISA in two population-based cohorts that included more than 6500 individuals. The Swiss Kidney Project on Genes in Hypertension study (SKIPOGH) included 817 adults (mean age±SD, 45±17 years) who underwent renal ultrasonography and performed a 24-hour urine collection. The Cohorte Lausannoise study included 5706 adults (mean age,

SUBMITTER: Pruijm M 

PROVIDER: S-EPMC4702229 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature