Clinical, Genetic, and Urinary Factors Associated with Uromodulin Excretion.

ABSTRACT:

Background and objectives

The urinary excretion of uromodulin is influenced by common variants in the UMOD gene, and it may be related to NaCl retention and hypertension. Levels of uromodulin are also dependent of the renal function, but other determinants remain unknown.

Design, setting, participants, & measurements

We tested associations between the urinary excretion of uromodulin; medical history and medication; serum and urinary levels of electrolytes, glucose, and uric acid; and the genotype at the UMOD/Protein Disulfide Isomerase-Like, Testis Expressed locus (rs4293393 and rs12446492); 943 participants from the CARTaGENE Cohort, a random sample from the Canadian population of 20,004 individuals, were analyzed. Participants with available genotyping were obtained from a

SUBMITTER: Troyanov S 

PROVIDER: S-EPMC4702232 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature