Identification and classification of small molecule kinases: insights into substrate recognition and specificity.

ABSTRACT:

Background

Many prokaryotic kinases that phosphorylate small molecule substrates, such as antibiotics, lipids and sugars, are evolutionarily related to Eukaryotic Protein Kinases (EPKs). These Eukaryotic-Like Kinases (ELKs) share the same overall structural fold as EPKs, but differ in their modes of regulation, substrate recognition and specificity-the sequence and structural determinants of which are poorly understood.

Results

To better understand the basis for ELK specificity, we applied a Bayesian classification procedure designed to identify sequence determinants responsible for functional divergence. This reveals that a large and diverse family of aminoglycoside kinases, characterized members of which are involved in antibiotic resistance, fall into major sub-groups bas

SUBMITTER: Oruganty K 

PROVIDER: S-EPMC4702295 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature