Polygenic analysis and targeted improvement of the complex trait of high acetic acid tolerance in the yeast Saccharomyces cerevisiae.

ABSTRACT:

Background

Acetic acid is one of the major inhibitors in lignocellulose hydrolysates used for the production of second-generation bioethanol. Although several genes have been identified in laboratory yeast strains that are required for tolerance to acetic acid, the genetic basis of the high acetic acid tolerance naturally present in some Saccharomyces cerevisiae strains is unknown. Identification of its polygenic basis may allow improvement of acetic acid tolerance in yeast strains used for second-generation bioethanol production by precise genome editing, minimizing the risk of negatively affecting other industrially important properties of the yeast.

Results

Haploid segregants of a strain with unusually high acetic acid tolerance and a reference industrial strain were used

SUBMITTER: Meijnen JP 

PROVIDER: S-EPMC4702306 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature