A multi-factorial analysis of response to warfarin in a UK prospective cohort.

ABSTRACT:

Background

Warfarin is the most widely used oral anticoagulant worldwide, but it has a narrow therapeutic index which necessitates constant monitoring of anticoagulation response. Previous genome-wide studies have focused on identifying factors explaining variance in stable dose, but have not explored the initial patient response to warfarin, and a wider range of clinical and biochemical factors affecting both initial and stable dosing with warfarin.

Methods

A prospective cohort of 711 patients starting warfarin was followed up for 6 months with analyses focusing on both non-genetic and genetic factors. The outcome measures used were mean weekly warfarin dose (MWD), stable mean weekly dose (SMWD) and international normalised ratio (INR) > 4 during the first week. Samples wer

SUBMITTER: Bourgeois S 

PROVIDER: S-EPMC4702374 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature