Efficient and automated large-scale detection of structural relationships in proteins with a flexible aligner.

ABSTRACT:

Background

The total number of known three-dimensional protein structures is rapidly increasing. Consequently, the need for fast structural search against complete databases without a significant loss of accuracy is increasingly demanding. Recently, TopSearch, an ultra-fast method for finding rigid structural relationships between a query structure and the complete Protein Data Bank (PDB), at the multi-chain level, has been released. However, comparable accurate flexible structural aligners to perform efficient whole database searches of multi-domain proteins are not yet available. The availability of such a tool is critical for a sustainable boosting of biological discovery.

Results

Here we report on the development of a new method for the fast and flexible comparison of pr

SUBMITTER: Gutierrez FI 

PROVIDER: S-EPMC4702403 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature